The player does not die simply by coming into contact with enemies, and correspondingly, many of the enemy troops also have melee attacks. In addition to shooting, the player can also perform melee attacks by using a knife and/or kicking. The tank is known as the SV-001 ('SV' stands for Super Vehicle), which not only increases the player's offense, but considerably adds to their defense.

On the way through each level, the player can find numerous weapon upgrades and 'Metal Slug' tanks. At this point, the player confronts a boss, who is usually considerably larger and tougher than regular enemies. Gameplay in Metal Slug 2 is very similar to the previous game the player(s) must shoot constantly at a continual stream of enemies in order to reach the end of each level. The game added several new features to the gameplay of the original Metal Slug, such as new weapons, vehicles and the ability to transform the character. It has been ported to the Neo Geo CD, PlayStation, Virtual Console, iOS and Android, and to the Wii, PlayStation Portable and PlayStation 2 (as part of the Metal Slug Anthology). It was re-released in 1999 in a slightly modified form as Metal Slug X: Super Vehicle-001 ( メタルスラッグ X). It was originally released in 1998 for the Neo-Geo MVS arcade platform as the sequel to the popular 1996 game Metal Slug. Metal Slug 2: Super Vehicle-001/II ( メタルスラッグ 2) is a run and gun video game developed by SNK.

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